During which phase does DNA exist as chromatin in eukaryotic cells?

DNA exists as chromatin in eukaryotic cells during interphase. This phase represents the period when the cell is not undergoing division and is focused on growth and metabolic activities. The DNA is in a relaxed, unraveled state known as chromatin, which allows for the necessary transcription and replication processes to occur effectively.

When the cell prepares to divide, particularly during prophase, the chromatin condenses into distinct chromosomes, making them easier to separate during mitosis. In metaphase, chromosomes are lined up at the cell's equator, and during anaphase, they are pulled apart to opposite poles of the cell. Therefore, interphase is essential for DNA transcription and replication, with chromatin allowing for these processes to take place efficiently.